Team

Principal Investigators

Christian T. Happi, PhD

Contact

Professor of Molecular Biology and Genomics in the Department of Biological Sciences
Director African Center of Excellence for Genomics of Infectious Diseases (ACEGID)

Full bio: Redeemer’s University Redemption City, Nigeria

Dr. Happi received his PhD in Molecular Parasitology from the University of Ibadan and completed his postdoctoral training at the Harvard School of Public Health. For this Core, Dr. Happi will oversee the direction and strategy of this program as the Research Hub Director, multi-PI and Core Lead of the Administrative Core.

He has a broad background in molecular biology and genomics with application in infectious disease, including malaria, Lassa fever, Ebola virus disease and HIV. One of his most meaningful accomplishments was the use of genomics technologies for early diagnosis and confirmation (within 6 hours) of Ebola virus disease (EVD) in Nigeria. This singular action was major in containing EVD in Nigeria, and therefore saving millions of lives in Africa. Additionally, he pioneered and rooted in Nigeria, nation-wide collaborations to make major breakthroughs in malaria, Lassa fever and Ebola Virus disease. With funding from the World Bank and the NIH, along with collaborators he established at Redeemer’s University, Nigeria, the African Center of Excellence for Genomics of Infectious Diseases (ACEGID, www.acegid.org) in 2013. This center with state-of-the-art genomics laboratories in its short history, has been transforming and positively impacting the health research in Africa by patients’ bedsides and will have a major role in CAMRA.

Stephen Obaro, MD, PhD

MPI

Professor, Division of Pediatric Infectious Diseases

Full bio: University of Nebraska Medical Center (UNMC)

Dr. Obaro received his medical degree from Ahmadu Bello University Zaria, Nigeria and his PhD in Immunology from the University of London. He specialized in Pediatric Infectious Diseases including Pneumococcal disease and vaccine, meningococcal disease and vaccine, HIV infections in children, typhoid fever in children, community acquired pneumonia and invasive bacterial infections in Nigerian children. He is an overall CAMRA multi-PI and PI of both projects. For Project 1, Dr. Obaro will coordinate genomic sequencing of bacterial isolates from Nigeria and Rwanda and oversee development of the antibiogram from both sites. For Project 2, he will be responsible for managing an international team for the development of a diagnostic platform for detecting specific antimicrobial resistance proteins and a novel antimicrobial drug.

He is currently a Professor of Pediatric Infectious Disease and Director of Pediatric International Research at the University of Nebraska Medical Center (UNMC). His training and work spans three continents, which has provided him with a unique experience in several aspects of clinical and laboratory medicine. His long-term goal and vision is to stimulate interest in infectious diseases for future generations of physicians and scientists in Nigeria. During the past decade, he has worked with different tertiary institutions and government agencies in Nigeria on several health related subjects, ranging from Polio eradication, control of meningococcal meningitis and enhancement of routine immunization coverage in northern Nigeria. The opportunity to investigate the epidemiology of Community-Acquired Bacteremic Syndromes in Young Nigerian Children (CABSYNC) and later, Community-acquired Pneumonia and Invasive Bacterial Diseases (CAPIBD) provided a platform to engage with several University hospitals, attending physicians, resident doctors, medical students and Laboratory Scientists across the country. He is also the co-founder and trustee for the International Foundation Against Infectious Disease in Nigeria (IFAIN), a non-governmental, not-for-profit organization that provides in-country oversight for my funded research projects.

Derrick E. Fouts, PhD

MPI

Professor of Genomic Medicine and Infectious Diseases

Full bio: J. Craig Venter Institute (JCVI), USA

Dr. Fouts has a Ph.D. in Microbiology and is a Professor in the Department of Genomic Medicine at the JCVI. He is a multi-PI and PI of the Data Management and Analysis Core (DMAC) with responsibility for the technical oversight of the DMAC and all activities at JCVI. He will interact with the overall PI to optimize genomic analysis strategies and to help train and increase informatics analysis capacity in Africa.

He has over 30 years of experience and over 100 publications in molecular microbiology, bacteriophage and bacterial genetics and genomics, synthetic genomics, bioinformatics and metagenomics. He was the Project Director of the NIAID-funded GCID Bacterial Project, which sequenced and compared over 2,000 genomes of both Gram-negative and Gram-positive pathogens to understand the molecular basis and transfer of antimicrobial resistance (AMR) genes, working with a large network of clinicians, including Dr. Obaro and Dr. Bonomo (Cleveland VA). Previous collaboration with Dr. Obaro resulted in genomic characterization of NDM5-containing Klebsiella quasipneumoniae that was responsible for a neonatal outbreak in Nigeria (PMC6416368). Under GCID funding, he co-developed Ometa with Indresh Singh, an ontology-based, data-driven metadata tracking system, to track all of our metadata for the GCID bacterial project (PMC6322262). He also worked with the US CDC to create a comprehensive, functional public health database of AMR genes and AMR gene tracking tool. Lastly, co-developed PanOCT, a pan-genome software tool that clusters orthologs using conserved gene neighborhoods and the pan-genome visualization software, PANACEA. These tools and others he helped co-develop will be used to analyze the bacterial genomes sequenced in CAMRA Project 1.

Team Members

Ian C. Michelow, MD, MMed, DTM&H

Site PI

Connecticut Children's Medical Center, University of Connecticut School of Medicine

Dr. Michelow’s experience and interests span clinical, basic and translational research topics with an emphasis on mechanisms of infection across microbial kingdoms, host-pathogen interactions and immune-mediated interventions. His research activities have included the study of malaria pathogenesis and vaccines, Ebola virus disease, clinical epidemiology and biomarkers of bacterial and viral infections in children including COVID-19, congenital syphilis, and pediatric osteoarticular infections, among others. He has also contributed to medical education by mentoring students on emerging infectious diseases research projects under an NIH-sponsored grant. Dr. Michelow collaborates with colleagues nationally and internationally. His research has been supported by several NIH grants including NIAID K08/U19/R25, NIGMS COBRE, and Fogarty U54. He has a patent for a malaria vaccine pending.

Mohamed Draz, PhD

Co-Investigator

Case Western Reserve University

He is the Director of the Draz Laboratory for Infection and Technology (InfecTec) at Case Western Reserve University. Dr. Draz is an expert in developing micro- and nano- technologies with applications in biomedicine, particularly for infectious diseases. He has a PhD in Infectious Diseases and six years of training in biomedical and health engineering at Harvard and the University of British Columbia. Dr. Draz’s research focus spans disease diagnosis and monitoring—using point-of-care (POC), rapid diagnostics, and mobile and digital health systems, and disease treatment—using gene-based, microbial, and nanoparticle therapeutics, vaccines, and tissue models and engineering. His research targets include (i) infections (HIV-1, TB, HPV, HBV, MRSA, Zika, etc.) and (ii) infection-associated health conditions—neurodegenerative, cardiovascular, blood, kidney, and cancer, and the microbiome.

Onikepe Folarin, PhD

Co-Investigator

ACEGID, Redeemer's University

I am a Professor of molecular biology and genomics and the deputy director of African Center of Excellence for Genomics of Infectious Diseases (ACEGID) where we train African scientists and research in the field of Genomics. I received training in Molecular Biology at the Malaria Research Laboratories, IAMRAT, the University of Ibadan from 2000 - 2009 during my PhD and post-doctoral training. I have a track record of research in the molecular mechanism of antimalarial drug resistance and molecular epidemiology of drug resistance. In the past 10 years, I have been involved in human genomics and Lassa fever genomics, through NIAID and NIH-funded projects as well as the 1000 Genome project in which I am a research team lead in Nigeria. I am also actively involved in research on pathogen detection, characterization, and surveillance

Umut A. Gurkan, PhD

Co-Investigator

Case Western Reserve University

Umut A. Gurkan, Ph.D., is a professor at Case Western Reserve University. Dr. Gurkan holds a Ph.D. degree in Biomedical Engineering from Purdue University and completed his postdoctoral training at Harvard Medical School. Dr. Gurkan’s research is on global equitable access to diagnostics and personalized health. Dr. Gurkan is a leader in the translation of microfluidics and point-of-care diagnostics for blood disorders and cancer. Dr. Gurkan is a member of the Global Gene Therapy Initiative, American Society of Mechanical Engineers, Biomedical Engineering Society, and American Society of Hematology. Dr. Gurkan is a Senior Member of the National Academy of Inventors, a member of the New Voices in Science, Engineering and Medicine Program by the National Academies of Sciences, Engineering, and Medicine, and a fellow of the American Institute for Medical and Biological Engineering.

Xu Li, PhD

Co-Investigator

Full Bio: University of Nebraska-Lincoln

Xu Li is a professor in the Department of Civil and Environmental Engineering at the University of Nebraska-Lincoln. He received his PhD in Environmental Engineering from the University of Michigan in 2008. His research revolves around microbes important to environment quality and public health. By working at the interface of environmental engineering and applied microbiology, his research group aims to advance knowledge on microbial communities relevant to contaminant biotransformation, resource recovery, and antibiotic resistance. He develops technologies and interventions to prevent and minimize pollution of water, soil, and crops and to protect human health from pollution. Specifically, he designs and optimizes engineering systems for drinking water treatment, wastewater reuse, and stormwater management, as well as agricultural practices for manure storage and land application.

Claude M Muvunyi MD PhD

Co-Investigator

ERC

I graduated in Medicine from the University of Rwanda, and then specialized in Clinical Microbiology and obtained PhD in medicine from Ghent University, Belgium. I am currently a full professor of clinical Microbiology and Laboratory Medicine at the University of Rwanda (UR). I have substantial clinical and public health expertise in public health laboratory and Antimicrobial resistance that I obtained through working with several agencies including public health institutions, regional and international non-government health implementing partners, universities, and multilateral organizations. My research interests include evaluation of diagnostic methods (molecular and serological) for infectious diseases and Antimicrobial Resistance (AMR) surveillance. I have published papers in several international and regional peer-reviewed journals.

Indresh K. Singh, MS

Co-Investigator, Data Management

Full bio: J. Craig Venter Institute (JCVI), USA

Mr. Singh has a MS in Computer Science and Engineering and is the Manager of Core Informatics Services at JCVI. He will lead the deployment of JCVI-developed analysis pipelines on ACEGID IT infrastructure. Mr. Singh will also train and advise ACEGID informatics staff on data depositions to public repositories.

He has developed and managed data collection, data management and data analysis tools/pipelines, including JCVI Laboratory Information Management System (JLIMS), Genome analysis (WGS metagenomics, 16S rDNA analysis, de novo assembly, SNP and INDEL analysis), and coordinated data delivery to customers/collaborators and public repositories including dbGap, GenBank, SRA. He co-developed and published, with Dr. Fouts, the OMeta data management web application (PMC6322262) that will be used in the DMAC. Mr. Singh also co-developed, with Dr. Fouts, an AMR database for the CDC to track the spread of antibiotic resistance.

Alice Nyamwiza

Managing Director

Eagle Research Center

Alice has a master’s degree in Global Health Policy and Management from Brandeis University, USA and had her Bachelor’s degree in Social Work and Social Administration from Uganda Christian University, Mukono. She is currently the Managing Director of Eagle Research Center, a private not for profit Research Institution in Rwanda.

With over 7 years of experience in Project/Grants Management and Human Resource, Alice has previously worked with several institutions including Imbuto Foundation and Tulane University International-Rwanda.

Jessica N. Uwanibe

Molecular Biologist

ACEGID, Redeemer's University

Currently a Ph.D. research fellow at the African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer’s University, Nigeria, where her research focuses on the use of genomics tools/techniques and bioinformatic tools for pathogen genomics surveillance, epidemiology and to understand the genetic diversity of pathogens of public health concern. Her research experiences consist of typhoid fever seroprevalence, antimicrobial resistance surveillance in Enterics in the Nigerian population and other pathogenic microbes (M. tuberculosis, C. auris, Yellow fever virus). Also involved in diagnostics development/ validation of a CRISPR-based rapid diagnostic for SARS-CoV-2 detection. Her role in CAMRA is to oversee the sequencing of samples in the project and training on bacteria next-generation sequencing.

Johnson Okolie, MBBS, MScPH

Assistant Project Manager

Redeemer's University

A global-health program and grants manager with over 8 years’ experience in international health programs, health research, training, capacity building and strengthening of local capacity for innovation and development. I draw my inspiration from lives saved and impacts left in communities through resilient health systems, application of evidence-based knowledge and utilization of local resources.

Richard Oyinloye (PGD Computer Science)

IT Manager

ACEGID, Redeemer's University, Ede, Osun State

A seasoned IT Manager that is solution oriented, highly analytical, and resourceful professional, with more than 20 years of experience in all phases of IT. He provides hardware, software & networking support at the ACEGID Genome Centre and sentinel sites across Nigeria and in Senegal, Sierra Leone, Liberia, & DRC. He obtained PGD in Computer Science from Lagos State University and has managed IT departments for several organizations including the Lacasera Group of Companies, Channel Technologies Ltd, Ritod technologies Ltd, Digitel/Systems Worldwide Ltd, etc. He is an expert in Microsoft Windows/Linux Administration and automation of business processes using the cutting-edge technologies and best practices.

Olanrewaju Eniade

Senior Data Manager

International Foundation Against Infectious Disease in Nigeria

Olanrewaju Davies Eniade has over seven years of experience in Health research. He earned a Bachelor of Science in Statistics and a Master of Science in Biostatistics from the University of Ibadan in Nigeria and currently a PhD candidate in the same department. He works at the International Foundation Against Infectious Diseases in Nigeria as a Senior Data Manager and has collaborated with the Institute of Human Virology, Nigeria. He helped improve the quality of data collection instruments and research output through the application of statistical techniques and research methods. He is also working as an adjunct lecturer of Biostatistics at Adeleke University, Ede Osun State. Olanrewaju has worked on lots of research projects and has several papers published in open-access journals. Also, he is a peer reviewer and editor for the EC Nursing and Healthcare Journal and the Journal of Pharmaceutical Research International. Through these experiences, he developed strong project coordination, implementation skills, data management and data analysis. Olanrewaju enjoys focusing on the topics of statistical methodology, infectious diseases, and sexual and reproductive health and has a strong passion for modelling the risk & risk factors of diseases using Machine Learning/Artificial Intelligence.

Stephen Rulisa, MD, FCOG (ECSA), PhD

Senior Consultant and Professor of Obstetrics and Gyneacology

University Teaching Hospital of Kigali

Prof Stephen Rulisa is a Senior Consultant Obstetrician gynecologist and researcher at the University Teaching Hospital of Kigali, with PhD in public health from Academic Medical Center, University of Amsterdam. Has over 19 years of research and clinical experience including:

  • Former Dean of School of Medicine and Pharmacy, University of Rwanda & Currently serving as a Clinician and Professor in the Department of Obstetrics and Gynecology, University of Rwanda, with other adjunct appointments at International Universities.
  • Founded and chaired the department of education and research at University Teaching hospital of Kigali, Founding fellow of East Central and Southern African College of obstetricians and gynecologists (ECSACOG) and Currently Chair of Education and Research Standing committee for ECSACOG.
  • Member of East African Community Health Research Commission (EAHRC) - Expert Working Group on Research and Capacity Development
  • Former President of Rwanda Medical Association, Current Board member of Rwanda Medical Council and Rwanda Medical Journal, among others.
  • Has made significant contributions to peer-review journals with over 100 publications as well as serving as an associate editor and board member for BMC Pregnancy and Childbirth, PLOS one, Current Obstetrics & Gynecology Reports, and Rwanda Medical Journal.

Iguosadolo (Dolo) Nosamiefan

Hub Administrator

Redeemer’s University, Nigeria

Mr. Nosamiefan is a project manager at the African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer’s University and will serve as the CAMRA Research Hub Administrator. Mr. Nosamiefan brings over 4 years of project management and grants administration experience on various infectious diseases efforts based around microbial infectious diseases. For this research hub, he will manage the administration of the grant award, coordinate the project logistics and meetings (both virtual and in-person), monitor project timelines, organize data and resource sharing between CAMRA projects/core and with the wider DS-I Africa Consortium. Additionally, Mr. Nosamiefan will coordinate the pilot project program in years 2-5 of this award.

Javan Okendo, PhD

Bioinformatician

ACEGID, National Human Genome Research Institute (National Institutes of Health)

Dr. Javan Okendo received his PhD in Chemical and Systems Biology from University of Cape Town, school of medicine, in South Africa where he studied what constitute susceptibility and protection to Mycobacterium tuberculosis (M. tb) infection from individuals with a broad spectrum of M. tb infection. He has also trained with Professor Nicola Mulder, to study within-host evolution of Plasmodim falciparum during treatment with artemether-lumefantrine. Since October, 2022 he has been at the National Human Genome Research Institute, National Institutes of Health, where his main research focuses on genome assembly and annotation of Zebrafish and paradise fish genomes. He is also a bioinformatician at the African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer’s University, Nigeria where he offers bioinformatic support and data analysis.

Yun (Renee) Zhang, PhD

Biostatistics

Full bio: J. Craig Venter Institute (JCVI), USA

Dr. Zhang is an Assistant Professor in the Informatics Department at the J. Craig Venter Institute (JCVI). She received an MMath in Mathematics and Statistics from the University of Oxford, UK, and a PhD in Statistics from the University of Rochester Medical Center. She also has industrial and research experience in Novartis Oncology and Mayo Clinic. Her research interest includes statistical modeling and methodology development for big data produced by advanced biotechnologies.

Dr. Zhang has extensive experience in multiple disciplines including mathematics, statistics, bioinformatics, and computational biology. As doctoral student at the University of Rochester and as a biostatistics intern at the Mayo Clinic, her research focused on statistical methodology development of gene set enrichment analysis (GSEA) and DNA methylation sequencing data analysis. Dr. Zhang’s role in CAMRA will be to consult with Project Leads regarding power calculations on sub-projects and will contribute to study design and rationale.

Daniella Matute, MSc

Bioinformatics Engineer

J. Craig Venter Institute (JCVI), USA

Ms. Matute is a bioinformatics engineer at JCVI. She has an MSc in Synthetic Biology and Biotechnology from the University of Edinburgh and a BS in Biology from George Mason University. Her experience encompasses multidisciplinary topics such as lab-automation, metagenomics, NGS, systems modeling and more. Currently she develops, maintains, integrates, and deploys bioinformatic tools and software supporting the project’s mission.

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Matthew LaPointe, MBA

Web Design & Communications

J. Craig Venter Institute (JCVI), USA

Mr. LaPointe is the director of web and creative services and media contact for JCVI. His role in the DMAC is leading design and content for the for the CAMRA website. He has worked at the JCVI for nearly 20 years focused on communication of scientific information to both lay and scientific audiences. His contributions include supporting educational outreach, scientific communications, and institutional development through web development, graphic design, social media, written communications, marketing, and events.

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Ryan Johnson

Website Development

J. Craig Venter Institute (JCVI), USA

Mr. Johnson is a Web Developer at JCVI. His role in the DMAC is to build the CAMRA website.